服務熱線:0377-63105569

輸血管理

MANAGEMENT

輸血管理

奥门威尼斯网址服務熱線:0377-63105569

奥门威尼斯网址地址:河南省南陽市長江西路168號

輸血管理

當前位置: 首頁>> 輸血管理

【輸血縱覽】小兒腫瘤患者輸注病原滅活技術處理的紅細胞的安全性和有效性

分類:輸血管理   來源:   日期:2019-03-26 11:01:12

 26.jpg

奥门威尼斯网址病原體減少技術(PRT)是目前常用的滅活血小板和血漿中多種病原體的技術。然而,由于紅細胞的脆弱性和吸收特性,全血或紅細胞的PRT并沒有得到很好的發展。為了研究PRT處理過的全血中的紅細胞的安全性和有效性,研究人員在輸注?射線照射的紅細胞(N=35)或PRT處理的全血的紅細胞(核黃素和紫外線)(N=35)后,對各種癌癥患兒(中位年齡為3.1歲)進行了30天的隨訪。血紅蛋白濃度的增加在兩組中相似。兩組輸血相關不良反應均較輕,發生率均為5.7%。PRT可能是一種合適的替代?射線照射的方法,以確保那些輸血相關的移植物抗宿主病的高風險者紅細胞輸注的安全性。需要進行更大規模的研究,以進一步確保經PRT處理的紅細胞的安全性和臨床有效性。

 

原文:Pathogen reduction technology (PRT) is now commonly used to inactivate many types of pathogens in platelets and plasma. PRT for whole blood or RBCs, however, is not as well developed due to the fragility and absorption characteristics of RBCs. In order to investigate the safely and effectiveness of RBCs from PRT treated whole blood, researchers followed pediatric patients (median age, 3.1) with various cancers for 30 days after transfusion with either ?-irradiated RBCs (N=35) or RBCs from PRT treated whole blood (riboflavin and UV light) (N=35). Increases in hemoglobin concentration were similar in both groups. All transfusion associated adverse events were mild and rates were the same in both groups (5.7%). PRT may be a suitable alternative to ?-irradiation for ensuring RBCs are safe for those at risk for transfusion-associated graft-vs-host disease. Larger studies are needed to further ensure the safety and clinical effectiveness of PRT-treated RBCs.

奥门威尼斯网址  

奥门威尼斯网址 版權所有 Copyright ? 2013 www.keriyas.com   服務熱線:0377-63105569

奥门威尼斯网址地址:河南省南陽市長江西路168號    技術支持:漢都商網